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Updated: Sep 6, 2025

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Developer's Guide to an Organ-on-Chip Model.

Julia Rogal¹, Katharina Schlünder^1,2, Peter Loskill^1,2,3

¹Department for Microphysiological Systems, Institute of Biomedical Engineering, Eberhard Karls University Tübingen, Tübingen 72074, Germany.

ACS Biomaterials Science & Engineering

|June 27, 2022

Summary

This summary is machine-generated.

This perspective outlines the organ-on-chip development process, integrating engineering and biology. It offers a stepwise guide for creating these complex tissue models for various applications.

Keywords:

in vitro models microfluidics microphysiological systems organ-on-chip tissue chips tissue engineering

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Area of Science:

Tissue Engineering
Biomedical Engineering
Microfluidics

Background:

Organ-on-chip (OOC) research is a rapidly advancing field within tissue engineering.
Developing OOC models necessitates an interdisciplinary approach, combining microfabrication, microfluidics, biomaterials, stem cell biology, and medicine.

Purpose of the Study:

To provide a conceptual, stepwise guide for the holistic development of organ-on-chip models.
To summarize key learnings and findings from a developer's perspective.
To identify introductory reviews for OOC development.

Main Methods:

The perspective follows the OOC journey through eight distinct stages: idea generation, design, engineering, biology considerations, cell/tissue assembly, assay development, functional validation, and application.
It integrates insights from microfabrication, microfluidics, biomaterials, stem cell science, and toxicology.

Main Results:

A comprehensive overview of the organ-on-chip development pipeline is presented.
Key considerations and challenges at each stage are highlighted from a developer's viewpoint.

Conclusions:

Successful organ-on-chip development requires a systematic, interdisciplinary approach.
This guide aims to facilitate the creation of functional organ-on-chip models for research and application.