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Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
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Flexible Sensing Systems for Cancer Diagnostics.

Anne K Brooks1, Sudesna Chakravarty1, Vamsi K Yadavalli2

  • 1Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA.

Advances in Experimental Medicine and Biology
|June 27, 2022
PubMed
Summary

Flexible biosensors offer new ways to detect cancer early and monitor patients. These wearable and point-of-care devices are key for precision cancer profiling and personalized treatment strategies.

Keywords:
BiomarkersBiosensorsCancerFlexibleImplantableWearable

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Ultrasensitive technologies are crucial for precision cancer profiling, enabling early diagnosis and monitoring of prognosis, risk stratification, and recurrence.
  • There is a growing demand for point-of-care (POC) diagnostic devices, especially those that are flexible and wearable for continuous patient monitoring.

Purpose of the Study:

  • To provide an integrated engineering perspective on the development of flexible biosensing platforms for cancer monitoring.
  • To explore the design considerations, biomarker targets, and transduction mechanisms for these advanced devices.

Main Methods:

  • Review of integrated engineering approaches for flexible biosensor systems.
  • Analysis of various transduction mechanisms and biomarker detection strategies.
  • Discussion of different flexible biosensing platform types, including wearables, breath sensors, and implantables.

Main Results:

  • Flexible biosensing platforms, including wearable (on-skin, on-clothing), breath, and implantable sensors, are being developed for cancer monitoring.
  • These devices leverage ultrasensitive detection for early diagnosis and prognosis management.

Conclusions:

  • Flexible and wearable biosensors represent a significant advancement in point-of-care cancer diagnostics and monitoring.
  • Overcoming design challenges is essential for realizing comprehensive cancer biomarker panels for improved patient care and clinical decision-making.