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Epidemiology of pediatric sarcoma in Iran

Mehdi Azizmohammad Looha1, Atieh Akbari2, Mohammad Esmaeil Akbari3

  • 1Biostatistics, Pediatric Pathology Research Center, Research Institute for Children's Health, Tehran, Iran.

Cancer Reports (Hoboken, N.J.)
|June 27, 2022
PubMed

Insights

This study found lower incidence and survival rates for pediatric soft-tissue sarcomas (STSs) and malignant bone tumors (MBTs) in Iran compared to high-income countries. Improving cancer registries is crucial for better sarcoma prevention and control.

Area of Science:

  • Pediatric oncology
  • Cancer epidemiology
  • Sarcoma research

Background:

  • Pediatric sarcomas encompass soft-tissue sarcomas (STSs) and malignant bone tumors (MBTs).
  • Understanding the epidemiology of these rare cancers is vital for public health initiatives.

Purpose of the Study:

  • To determine the incidence and survival rates of pediatric STSs and MBTs in Iran.
  • To analyze these rates based on diagnosis date, gender, age, and histological types.
  • To compare Iranian data with international benchmarks.

Main Methods:

  • Utilized data from the Iran National Cancer Registry (2008-2015).
  • Classified cases according to the International Classification of Childhood Cancer (3rd ed.).
  • Calculated age-standardized incidence rates (ASIRs) and five-year survival rates for available data.

Main Results:

  • Survival data was available for only 21% of pediatric sarcoma cases.
  • Incidence and survival rates for MBTs and STSs in Iran were lower than in high-income countries.
  • Survival rates for these malignancies were significantly lower in Iran compared to high-income nations.

Conclusions:

  • This is the first comprehensive study on pediatric sarcomas in Iran.
  • The findings highlight disparities in incidence and survival rates compared to high-income countries.
  • There is an urgent need to enhance the quality and quantity of Iran's population-based cancer registries for improved sarcoma management.
Abstract

Keywords:
Iran national cancer registryepidemiologymalignant bone tumorosteosarcomapediatric sarcomarhabdomyosarcomasoft tissue sarcoma

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