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A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
Published on: April 7, 2014
Differences in strength, leg lean mass, and lifestyle factors between premenopausal and perimenopausal women
Hannah E Cabre1,2, Lacey M Gould1, Amanda N Gordon1
1Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Background:
Menopausal changes coupled with age-related reductions in muscle strength can impact functionality.
Aim:
To evaluate the differences in muscle strength, dominant leg lean mass (DLMleg ), relative protein intake (r_PRO) and physical activity (PA) between premenopausal (PRE) and perimenopausal (PERI) women.
Methods:
Twenty-four PRE- (age = 39.8 ± 3.3 years; BMI: 25.3 ± 5.0 kg/m2 ) and 24 PERI-women (age = 50.0 ± 3.3 years; BMI: 26.5 ± 5.4 kg/m2 ) participated in leg extensor isometric peak force (PF), DLMleg , r_PRO and PA. Independent samples t-tests and one-way analyses of covariance covaried for age and DLMleg were used to compare groups.
Results:
The PRE group had significantly higher PF (mean difference ± standard error: 57.8 ± 28.0 N; p = 0.045) and DLMleg (0.7 ± 0.3 kg; p = 0.031) when compared to the PERI group. There were no significant differences in r_PRO, or PA between groups (p = 0.173-0.423). When covaried for age and DLMleg , there was no significant difference in PF (p = 0.982 and 0.405, respectively).
Conclusions:
Age and DLMleg may be important contributors to menopause-phase related differences in strength.
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