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[Evidence-based standardized nutrition protocol can shorten the time to full enteral feeding in very preterm/very low

Lin Wang1, Xiao-Peng Zhao1, Hui-Juan Liu1

  • 1Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|June 28, 2022
PubMed

Insights

A new nutrition protocol significantly speeds up full enteral feeding and reduces parenteral nutrition duration in very preterm infants. This approach also lowers catheter-related bloodstream infections without increasing necrotizing enterocolitis risk.

Area of Science:

  • Neonatalogy
  • Pediatric Nutrition
  • Evidence-Based Medicine

Background:

  • Very preterm/very low birth weight infants often face challenges in establishing adequate nutrition.
  • Parenteral nutrition is frequently required but associated with risks.
  • Standardized protocols may optimize nutritional support and clinical outcomes.

Purpose of the Study:

  • To evaluate the impact of an evidence-based standardized nutrition protocol on achieving full enteral feeding.
  • To assess the effect of the protocol on short-term clinical outcomes in very preterm infants.

Main Methods:

  • Retrospective analysis of 312 preterm infants (gestational age ≤32 weeks or birth weight <1500 g).
  • Comparison of a control group (n=160) with a test group (n=152) using a standardized nutrition protocol implemented post-May 2020.
  • Key outcomes measured: time to enteral feeding, duration of parenteral nutrition, time to recovery of birth weight, central venous catheterization duration, and complication rates.

Main Results:

  • The test group showed significantly shorter times to start and full establishment of enteral feeding.
  • Duration of parenteral nutrition and central venous catheterization were significantly reduced in the test group.
  • A significantly lower incidence of catheter-related bloodstream infection was observed in the test group; no significant difference in mortality or necrotizing enterocolitis rates.

Conclusions:

  • The standardized nutrition protocol effectively facilitates full enteral feeding in very preterm infants.
  • The protocol leads to a shorter duration of parenteral nutrition and reduced catheter-related bloodstream infections.
  • Implementation of the protocol does not increase the risk of necrotizing enterocolitis.
Abstract

Keywords:
Enteral feedingStandardized nutrition protocolVery low birth weight infantVery preterm infant

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