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Updated: Sep 6, 2025

Chemical Triphosphorylation of Oligonucleotides
Published on: June 2, 2022
Blue LED-Promoted Syntheses of Phosphorothioates and Phosphorodithioates
Bo-Ru Shen1, Pratheepkumar Annamalai1, Shih-Fang Wang1
1Department of Chemistry, National Chung Hsing University, Taichung City, Taiwan 402, R.O.C.
Abstract:
An environmentally friendly and resourceful modular protocol for the synthesis of phosphorochalcogenoates, phosphorochalcogenothioates, and phosphinothioates under blue light-emitting diode irradiation is described. The blue LED-promoted P-S, P-Se, and P-Te bond constructions occurred under metal-free, ligand-free, oxidant-free, and photocatalyst-free conditions with minimum chemical waste generation and high atom economy providing the resulting phosphorochalcogenoates, phosphorochalcogenothioates, and phosphinothioates in good to excellent yields.
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