Prospective bidirectional associations between depression and chronic kidney diseases
Xiaowei Zheng1, Wenyan Wu2, Suwen Shen3
1Department of Public Health and Preventive Medicine, Wuxi School of Medicine Jiangnan University, 1800 Lihu Road, Binhu District, Wuxi, 214122, Jiangsu Province, China. zxw19921212@163.com.
Scientific Reports
|June 28, 2022
Summary
This study reveals a two-way link between depression and chronic kidney disease (CKD). Depression increases CKD risk, and CKD also elevates the likelihood of developing depression.
Area of Science:
- Nephrology
- Psychiatry
- Epidemiology
Background:
- Existing research suggests a link between depression and chronic kidney disease (CKD).
- The bidirectional nature of this relationship requires further investigation.
Purpose of the Study:
- To investigate the bidirectional relationship between depression and CKD.
- To assess if depression predicts subsequent CKD risk.
- To determine if CKD onset predicts depression development.
Main Methods:
- Utilized data from the China Health and Retirement Longitudinal Study (CHARLS) with participants over 45 years old.
- Employed multivariate logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs).
- Conducted sensitivity and subgroup analyses to confirm findings.
Main Results:
- Depression was associated with an increased risk of developing CKD (OR: 1.38, 95% CI: 1.08-1.76).
- CKD was linked to a higher risk of developing depression (OR: 1.48, 95% CI: 1.23-1.78).
- Bidirectional relationships were consistently observed across analyses.
Conclusions:
- Demonstrated a significant bidirectional relationship between depression and CKD.
- Individuals with depression face a higher risk of developing CKD.
- CKD patients exhibit an increased risk of developing depressive symptoms.
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