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Effect of Sofosbuvir on Length of Hospital Stay in Moderate COVID-19 Cases; a Randomized Controlled Trial

Rama Bozorgmehr1, Farbod Amiri2, Mohammad Hosein Zadeh3

  • 1Clinical Research Development Unit, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Archives of Academic Emergency Medicine
|June 29, 2022
PubMed
Abstract

Insights

Sofosbuvir treatment may reduce hospitalization duration for moderate COVID-19 patients. This antiviral did not significantly impact intensive care unit (ICU) admission or mortality rates in the study.

Area of Science:

  • Infectious Diseases
  • Virology
  • Clinical Medicine

Background:

  • The COVID-19 pandemic necessitates ongoing research into effective treatments.
  • Moderate severity COVID-19 cases require interventions to manage hospital stay and prevent complications.

Purpose of the Study:

  • To evaluate the efficacy of sofosbuvir in reducing hospital stay for moderate COVID-19 patients.
  • To assess the impact of sofosbuvir on complications, including intensive care unit (ICU) admission and mortality.

Main Methods:

  • A randomized clinical trial involving 100 moderate COVID-19 patients.
  • Patients were allocated to either sofosbuvir intervention or control groups.
  • Outcomes measured included length of hospital stay and complication rates.

Main Results:

  • The sofosbuvir group had a significantly shorter mean hospital stay (4.7 days) compared to the control group (7.7 days).
  • No significant difference was observed in the need for ICU admission or mechanical ventilation between groups.
  • Patient demographics and baseline characteristics were comparable between the intervention and control groups.

Conclusions:

  • Sofosbuvir shows potential in decreasing the length of hospital stay for moderate COVID-19.
  • The study found no significant effect of sofosbuvir on ICU admission or mortality in this patient cohort.
Keywords:
Duration of TherapySARS-CoV-2SofosbuvirTreatment Outcome

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