Access to high value sp3-rich frameworks using photocatalyzed [2 + 2]-cycloadditions of γ-alkylidene-γ-lactams
Dimitris Kalaitzakis1, Ioannis Kampouropoulos1, Manolis Sofiadis1
1Department of Chemistry, University of Crete, Vasilika Vouton, 71003, Crete, Greece. vasil@uoc.gr.
Abstract:
By harnessing an energy transfer process, new photocatalyzed [2 + 2]-cycloadditions occurring between γ-alkylidene-γ-lactams and unsaturated substrates have been developed. The reaction mode is particularly powerful because it leads to the formation of different high value sp3-rich frameworks and further diversity can be introduced through cascade sequences wherein strain releasing opening of the cyclobutane intermediates gives access to complex polycyclic alkaloid frameworks.
More Related Videos
07:12Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Related Concept Videos
Cycloaddition Reactions: Overview
Cycloaddition Reactions: MO Requirements for Thermal Activation
Cycloaddition Reactions: MO Requirements for Photochemical Activation
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
