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Aging and macrophages: Not standing the test of time?

Suhas Sureshchandra1,2, Ilhem Messaoudi3

  • 1Institute for Immunology, University of California, Irvine, California, USA.

Journal of Leukocyte Biology
|June 29, 2022
PubMed

Insights

Epigenetic dysregulation, not subtype loss, drives immunosenescence in alveolar macrophages, impacting their response to environmental stress.

Area of Science:

  • Immunology
  • Cellular Biology
  • Aging Research

Background:

  • Immunosenescence, the aging of the immune system, impairs host defense.
  • Alveolar macrophages are crucial for lung immunity and are susceptible to aging.
  • Environmental stressors further challenge immune function in the lungs.

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