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Updated: Sep 6, 2025
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Kollidon® VA 64 and Soluplus® as modern polymeric carriers for amorphous solid dispersions
Dominik Strojewski1, Anna Krupa1
1Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Kraków, Poland.
Polimery W Medycynie
|June 29, 2022
Summary
New drug delivery technologies are essential for poorly soluble drugs. Amorphous solid dispersions (ASDs) using polymers like Kollidon® VA 64 and Soluplus® enhance solubility and bioavailability, with advanced manufacturing methods improving stability.
Area of Science:
- Pharmaceutical Science
- Materials Science
Background:
- Growing number of poorly water-soluble drug candidates necessitates advanced formulation technologies.
- Amorphous solid dispersions (ASDs) offer enhanced solubility and controlled release but face stability challenges.
- Understanding polymeric excipients is crucial for developing stable ASDs.
Purpose of the Study:
- To review the application of Kollidon® VA 64 (copovidone) and Soluplus® in ASD manufacturing over the past 20 years.
- To explore both classical and advanced manufacturing technologies for ASDs.
- To highlight the role of these polymers in enhancing solubility and bioavailability of poorly soluble drugs.
Main Methods:
- Review of scientific literature on ASDs, Kollidon® VA 64, and Soluplus®.
- Analysis of classical methods (solvent evaporation, melting) and advanced techniques (pulse combustion drying, electrospinning, 3D printing).
- Evaluation of in vitro dissolution rates and in vivo bioavailability data.
Main Results:
- Kollidon® VA 64 and Soluplus® are effective polymeric carriers for enhancing solubility of poorly soluble drugs.
- Advanced manufacturing technologies offer improved methods for ASD production.
- Both polymers demonstrate potential in improving dissolution rates and bioavailability.
Conclusions:
- Kollidon® VA 64 and Soluplus® are valuable polymers for creating stable amorphous solid dispersions.
- Advanced manufacturing techniques can overcome traditional limitations in ASD production.
- These polymeric carriers facilitate enhanced solubility and bioavailability for poorly soluble active pharmaceutical ingredients.
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