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Updated: Sep 6, 2025

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
[Idiopathic pulmonary fibrosis]
Nathan Hennion1, Jean-Luc Desseyn1, Frédéric Gottrand1
1Univ. Lille, Inserm, CHU Lille, U1286 Infinite, F-59000 Lille, France.
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease of unknown origin. It is characterized by aberrant scarring of the alveolar epithelium leading to an accumulation of extracellular matrix (ECM). Fibroblastic foci, consisting of fibroblasts and myofibroblasts, are responsible for the excessive production of ECM. The two therapeutic molecules available on the market to date only allow to slow down the evolution of the disease. In this review, we present the mechanisms involved in the progression of the disease, its treatments and the study models.
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