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Published on: January 14, 2014
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Primary versus secondary gliosarcoma: a systematic review and meta-analysis.
1Department of Neurosurgery, Oklahoma University Health Sciences Center, Oklahoma City, OK, 73104, USA.
Journal of Neuro-Oncology
|June 29, 2022
Summary
Primary gliosarcoma (PGS) and secondary gliosarcoma (SGS) are rare brain tumors. While SGS patients are younger and have worse prognoses, both tumor types share similar genetic profiles, indicating distinct clinical behaviors.
Area of Science:
- Neuro-oncology
- Oncology
- Genetics
Background:
- Gliosarcomas are rare malignant brain tumors.
- Primary gliosarcoma (PGS) arises de novo, while secondary gliosarcoma (SGS) develops after glioblastoma treatment.
- Clinical and genetic differences between PGS and SGS remain unclear.
Purpose of the Study:
- To investigate clinicopathological features, prognostic survivals, and molecular profiles of PGS versus SGS.
- To compare clinical characteristics and outcomes between primary and secondary gliosarcomas.
- To elucidate potential genetic distinctions between these rare brain tumors.
Main Methods:
- Meta-analysis of eight studies including 239 PGS and 79 SGS cases.
- Searched PubMed and Web of Science databases.
- Pooled odds ratio (OR) and hazard ratio (HR) using random-effect models.
Main Results:
- SGS patients were younger, with lower rates of gross total resection and radiation therapy.
- SGS showed significantly worse progression-free survival (PFS) and overall survival (OS) compared to PGS.
- No significant differences in EGFR mutation, IDH mutation, or MGMT methylation between PGS and SGS.
Conclusions:
- PGS and SGS exhibit distinct clinicopathological profiles and prognoses.
- Despite differing clinical behaviors, PGS and SGS share similar genetic profiles.
- Further research is needed to understand the genetic pathways driving PGS and SGS.
Keywords:
EGFRGlioblastomaIDHMGMTOverall survivalPrimary gliosarcomaProgression-free survivalSecondary gliosarcoma
