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Congenital Solitary Functioning Kidney: A Review.
Eduarda Almeida Wakabayashi1, Alexandre Negrão Pantaleão1, Renata Araújo Avendanha1
1Interdisciplinary Laboratory of Medical Investigation, Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Current Medicinal Chemistry
|June 30, 2022
Summary
Solitary functioning kidney (SFK) can lead to kidney damage despite past beliefs. Novel urinary biomarkers like Cystatin C, EGF, and NGAL show promise for monitoring patients with SFK.
Area of Science:
- Pediatric Nephrology
- Urology
- Genetics
Background:
- Solitary functioning kidney (SFK) is a subgroup of Congenital Anomalies of the Kidneys and Urinary Tract (CAKUT).
- Historically, SFK prognosis was considered good, but current research indicates varying degrees of kidney damage.
- Serum creatinine is a limited marker for renal function assessment in SFK patients.
Approach:
- This review synthesizes current literature on congenital SFK.
- It covers pathophysiology, diagnosis, complications, prognosis, and treatment.
- The role of novel urinary biomarkers and follow-up strategies are discussed.
Key Points:
- The natural history of congenital SFK remains unclear.
- Brenner's hyperfiltration hypothesis is a leading theory for adverse renal outcomes.
- Urinary biomarkers such as Cystatin C, EGF, and NGAL show potential for SFK patient follow-up.
Conclusions:
- Longer follow-up studies are essential to understand congenital SFK's natural course.
- Further research on novel urinary biomarkers in SFK is crucial.
- Improved understanding will enhance patient prognosis and management.
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