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[Changes in brain energy metabolism in experimental cerebral hemorrhage]
Abstract:
Intracerebral hemorrhage impaired the functional activity of rat brain mitochondria. After experimental insult the rate of succinate and alpha-ketoglutarate oxidation was decreased at the states 3 and 4 in brain mitochondria as well as in presence of 2,4-dinitrophenol. The rate of phosphorylation was also decreased in oxidation of both NAD- and FAD-dependent substrates.