Related Experiment Video
Updated: Sep 6, 2025
09:29
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
30.4K
Vasoactive intestinal peptide: a potential target for antiviral therapy
Yu He1, Na Zang1, En-Mei Liu2
1Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China.
Sheng Li Xue Bao : [Acta Physiologica Sinica]
|June 30, 2022
Summary
Vasoactive intestinal peptide (VIP) shows promise as a novel antiviral therapeutic. Its efficacy against various viruses, including SARS-CoV-2, and its anti-inflammatory properties highlight its potential for treating viral infections.
Area of Science:
- Virology
- Immunology
- Drug Discovery
Background:
- Viral infections pose significant global health challenges with limited therapeutic options.
- Existing antiviral treatments often face issues like drug resistance and adverse effects.
- There is an urgent need for novel antiviral strategies, including peptide-based therapeutics.
Purpose of the Study:
- To review the role and mechanisms of Vasoactive Intestinal Peptide (VIP) in various viral infections.
- To evaluate the potential of VIP as a therapeutic target for antiviral defense.
- To highlight VIP's anti-inflammatory and immunoregulatory properties in the context of viral diseases.
Main Methods:
- Literature review of studies reporting VIP's involvement in viral infections.
- Analysis of VIP's mechanisms of action against viruses such as SARS-CoV-2, HIV, VSV, RSV, ZIKV, and CMV.
- Assessment of VIP's anti-inflammatory and immunomodulatory effects.
Main Results:
- VIP has demonstrated involvement in the defense against a range of viral infections.
- VIP exhibits potent anti-inflammatory and immunoregulatory capabilities.
- These properties suggest VIP can mitigate severe complications arising from overactive immune responses during viral attacks.
Conclusions:
- Vasoactive Intestinal Peptide (VIP) is a promising candidate for antiviral therapy.
- VIP's multifaceted actions, including direct antiviral effects and immune modulation, offer a unique therapeutic approach.
- Further clinical investigation into VIP as an antiviral agent is warranted.
Related Concept Videos
02:30siRNA - Small Interfering RNAs
17.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.0K
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
200
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
200
01:29Inflammatory Bowel Disease IV: Pharmacological Management
176
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
176
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
315
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
315
01:29Subviral Agents
103
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
103
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
539
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
539