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The Successive Alleys Test of Anxiety in Mice and Rats
Published on: June 17, 2013
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Structural connectome-based prediction of trait anxiety
Chaebin Yoo1, Sujin Park1, M Justin Kim2,3
1Department of Psychology, Sungkyunkwan University, Seoul, South Korea.
Brain Imaging and Behavior
|June 30, 2022
Summary
Trait anxiety prediction differs by age, with distinct brain connectivity patterns observed in younger adults compared to broader networks in mixed age groups. This highlights age-dependent effects on neurobiological markers for anxiety.
Area of Science:
- Neuroimaging
- Psychiatry
- Computational Neuroscience
Background:
- Trait anxiety is linked to amygdala-prefrontal circuitry, but findings are inconsistent, potentially due to age effects.
- Aging influences both trait anxiety levels and brain structural connectivity.
Purpose of the Study:
- To clarify the age-dependent relationship between brain structural connectivity and trait anxiety.
- To identify predictive neuroimaging biomarkers for trait anxiety.
Main Methods:
- Applied connectome-based predictive modeling to diffusion-weighted imaging data from 148 participants.
- Utilized the Leipzig Study for Mind-Body Emotion Interactions dataset.
- Analyzed whole-brain structural connectivity patterns predicting trait anxiety across different age groups.
Main Results:
- Predictive networks for trait anxiety varied significantly across age groups.
- Younger adults (20-30) showed an isolated negative network associated with amygdala-prefrontal circuitry.
- A widespread positive network (frontotemporal and frontolimbic) predicted trait anxiety in mixed age groups (20-80), but not in older adults (30-80) alone.
Conclusions:
- Trait anxiety prediction via structural brain connectivity is age-dependent.
- Findings support the development of age-specific neural biomarkers for anxiety.
- The study reveals distinct connectivity patterns related to trait anxiety in different age demographics.
Keywords:
AmygdalaConnectomeDiffusion-weighted imagingStructural connectivityTrait anxietyWhite matterMore Related Videos
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