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Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: Jun 28, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Modeling Asthma in Mice Using Common Aeroallergens.

Bidisha Paul Chowdhury¹, Magdalena M Gorska^2,3

¹Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA.

Methods in Molecular Biology (Clifton, N.J.)

|June 30, 2022

Summary

This chapter details four mouse models for studying aeroallergen-induced asthma. These models explore different asthma mechanisms using various allergens and exposure methods, aiding research into this common respiratory disease.

Keywords:

Aeroallergen Airway hyperresponsiveness Asthma Bronchoalveolar lavage Inflammation Mouse model Sensitization

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Last Updated: Jun 28, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

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Published on: April 13, 2010

Murine Model of Allergen Induced Asthma

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Published on: May 14, 2012

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

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Published on: July 10, 2018

Area of Science:

Immunology
Pulmonology
Animal Models

Background:

Aeroallergens trigger asthma in humans.
Aeroallergens are utilized in experimental research to create animal models of asthma.
Understanding asthma mechanisms is crucial for developing effective treatments.

Purpose of the Study:

To describe four distinct mouse models of aeroallergen-induced asthma.
To highlight the variations in these models regarding allergens, exposure, and adjuvant use.
To present common methods for mechanistic asthma studies in mice.

Main Methods:

Four mouse models of aeroallergen-induced asthma are described.
Methods include tracheotomy and bronchoalveolar lavage.
Analysis involves cytospin, morphologic assessment of lavage cells, and lung tissue processing.

Main Results:

The described models represent diverse mechanistic variants of asthma.
Standardized methods facilitate detailed mechanistic investigations.
These models provide a platform for studying asthma pathogenesis.

Conclusions:

The described mouse models offer valuable tools for asthma research.
Varied experimental approaches allow for comprehensive mechanistic studies.
These models contribute to a deeper understanding of aeroallergen-induced asthma.