Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

541
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
541
T Cell Types and Functions01:24

T Cell Types and Functions

954
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
954
Hypersensitivities01:30

Hypersensitivities

522
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
522
Vaccinations01:51

Vaccinations

44.1K
Overview
44.1K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

758
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
758
Active versus Passive Immunity01:31

Active versus Passive Immunity

575
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
575

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Update on environmental determinants of allergic diseases.

The Journal of allergy and clinical immunology·2026
Same author

CBX7 functions as a methylation-dependent inducer of gene transcription and regulator of cytosolic signaling in lymphoid cells.

Science advances·2026
Same author

Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-α signaling.

The Journal of clinical investigation·2025
Same author

Modeling Asthma in Mice Using Common Aeroallergens.

Methods in molecular biology (Clifton, N.J.)·2022
Same author

The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma.

The Journal of experimental medicine·2021
Same author

Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.

PLoS biology·2021

Related Experiment Video

Updated: Jun 7, 2025

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.4K

Update on type 2 immunity.

Magdalena M Gorska1

  • 1Department of Medicine, Division of Allergy and Clinical Immunology, National Jewish Health, Denver, and the Department of Medicine, Division of Allergy and Clinical Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colo.

The Journal of Allergy and Clinical Immunology
|November 11, 2024
PubMed
Summary

Recent advances reveal new roles for type 2 immunity in allergies, infections, and tissue repair. This review highlights key findings on immune cells, environmental factors, and therapeutic potential.

Keywords:
ILC2IgET(H)2 cellsType 2 immunityallergyasthmamast cellsneuroimmune interactions

More Related Videos

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

16.7K
High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

7.9K

Related Experiment Videos

Last Updated: Jun 7, 2025

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.4K
Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

16.7K
High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

7.9K

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Type 2 immunity involves cytokines like IL-4, IL-5, IL-9, and IL-13.
  • It plays roles in allergies, helminth infections, and tissue homeostasis.

Purpose of the Study:

  • To review mechanistic work on type 2 immunity from January 2022 to September 2024.
  • To discuss novel findings on its regulation and clinical significance.

Main Methods:

  • Literature review of mechanistic studies on type 2 immunity.
  • Analysis of recent findings on cellular and humoral factors.
  • Discussion of new mouse models and clinical implications.

Main Results:

  • Novel insights into the regulation of type 2 immunity by cells like ILC2s, T cells, mast cells, neurons, and IgE.
  • Discoveries on how environmental exposures and host factors modulate these immune responses.
  • Introduction of new genetic mouse models for accelerated research.

Conclusions:

  • Type 2 immunity has diverse roles beyond allergies and helminth infections, including tissue repair and metabolic health.
  • Recent discoveries offer new avenues for therapeutic interventions and drug development.
  • The field is advancing rapidly with new models and a deeper understanding of regulatory mechanisms.