Interventions for the Prevention of Preterm Premature Rupture of Membranes: A Systematic Review and Meta-Analysis
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Published on: January 7, 2020
Vanessa El-Achi1, Sangita Aggarwal2, Jon Hyett3,4
1Department of Maternal and Fetal Medicine, Liverpool Hospital, Sydney, New South Wales, Australia.
Insights
No current interventions effectively prevent preterm prelabour rupture of membranes (PPRoM). Further research is needed to address this significant cause of maternal and perinatal complications.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Evidence-Based Medicine
Background:
- Preterm prelabour rupture of membranes (PPRoM) is a critical factor in maternal and perinatal morbidity and mortality.
- Identifying effective interventions to reduce PPRoM prevalence is crucial for improving pregnancy outcomes.
Approach:
- A systematic literature search of major databases (MEDLINE, EMBASE, PubMed, Cochrane Library) was conducted.
- Randomized controlled trials comparing interventions to standard care for PPRoM were included.
- Risk of bias, odds ratios, and GRADE methodology were used for rigorous analysis.
Key Points:
- Twenty-nine studies evaluated ten interventions, including DHA, aspirin, folic acid, and micronutrient supplements.
- Most interventions showed no significant difference in PPRoM rates compared to placebo.
- Rofecoxib was associated with an increased risk, while a multiple micronutrient supplement showed a potential reduction, both with very low quality evidence.
Conclusions:
- Currently, no interventions are convincingly proven to reduce the incidence of PPRoM.
- Given the significant impact of PPRoM, further high-quality research is essential.
Introduction:
Preterm prelabour rupture of membranes (PPRoM) is a significant cause of maternal and perinatal morbidity and mortality. The aim of this project was to identify interventions that reduce the prevalence of PPRoM.
Methods:
Search strategy included a systematic literature search of MEDLINE, EMBASE, PubMed, and Cochrane Library. The selection criteria included randomized control studies that compared a therapy to standard care (no therapy or placebo) in pregnancy and included PPRoM as an outcome. Risk of bias was assessed according to the Cochrane risk-of-bias tool for randomized trials. Odds ratios with 95% confidence intervals were calculated using random-effects models. Quality of evidence was assessed using the GRADE methodology.
Results:
Twenty-nine studies examining 10 interventions met the inclusion criteria. Therapies included docosahexaenoic acid (DHA), aspirin, rofecoxib, vitamin C alone and with vitamin E, folic acid (alone, with iron, with iron and zinc, within a multiple micronutrient supplement), zinc, calcium, copper, and treatment of bacterial vaginosis. There was no significant difference in the prevalence of PPRoM in the treatment groups compared to placebo, except for rofecoxib which showed an increased risk of PPRoM (RR 2.46, 95% CI 1.28-4.73; p = 0.007, 1 trial, 98 women; very low quality of evidence) and a multiple micronutrient supplement which showed a reduction in PPRoM (RR 0.40, 95% CI 0.19-0.84; p = 0.01, 1 trial, 1,671 women; very low quality of evidence).
Conclusions:
No interventions have been convincingly shown to reduce the prevalence of PPRoM. Given this is a common problem leading to significant morbidity and mortality, further research is required.
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