[Does extensive small intestine resection prevent experimentally induced duodenal ulcers? A study on rats]

Our previous results showed that pentagastrin stimulated gastric secretion (peak acid output) was significantly decreased following extensive distal small bowel resection. The aim of this study was to see the effect of extensive small bowel resection on experimental duodenal ulcers 28 days after operation. We used secretagogue-produced duodenal ulcers in the rats. Vagotomy prevented these experimental ulcers but not gastric mucosa lesions. Extensive small bowel resection both proximally and distally prevented secretagogue-induced duodenal ulcers too, but there was a mucosa protection both in gastric antrum and duodenal bulb. We concluded this protective effect may be due to compensatory mucosa hyperplasia following extensive small bowel resection.