Related Experiment Video

Updated: Sep 6, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Protocol for a systematic review on routine use of antibiotics for infants less than 6 months of age with growth

Aamer Imdad1, Fanny F Chen2, Melissa François2

  • 1Division of Pediatric Gastroenterology, Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York, USA imdada@upstate.edu.

BMJ Open
|June 30, 2022
PubMed

Insights

This systematic review examines antibiotic effectiveness for infants under six months experiencing growth faltering. Evidence is limited, highlighting the need for better treatment guidelines for this vulnerable population.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Antibiotics are used for severe acute malnutrition in children (6-59 months).
  • Data on antibiotic use for infants under six months with growth failure is scarce.
  • The World Health Organization (WHO) is developing guidelines for infant wasting and growth faltering.

Purpose of the Study:

  • To systematically review and synthesize current evidence on antibiotic effectiveness in treating infants under six months with growth failure/faltering.
  • To inform WHO guideline development for preventing and treating wasting in young infants.
  • To address the lack of data for this specific age group.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials and non-randomized studies with a control arm.
  • Searches across multiple electronic databases.
  • Inclusion criteria: infants < 6 months with growth failure; intervention: no/alternative antibiotics; comparison: WHO 2013 guideline antibiotics.
  • Outcomes include mortality, clinical deterioration, antimicrobial resistance, and adverse events.

Main Results:

  • The review synthesizes evidence from eligible studies.
  • Meta-analysis will be used to pool data where applicable.
  • Evidence quality will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.

Conclusions:

  • Findings will be published in a peer-review journal.
  • The review will guide WHO recommendations on antibiotic use in infants < 6 months with growth failure.
  • This research addresses a critical knowledge gap in pediatric nutrition and infectious disease management.
Abstract

Keywords:
nutrition & dieteticsnutritional supportpaediatric gastroenterologypaediatric infectious disease & immunisationpublic health

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