Related Experiment Video

Updated: Sep 6, 2025

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

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Clot In Transit in a Patient with Protein S Deficiency

Simon Kashfi1, Mohamed Farhan Nasser2, Aron Soleiman3

  • 1CUNY School of Medicine, New York, NY, USA.

European Journal of Case Reports in Internal Medicine
|July 1, 2022
PubMed

Insights

Clot in transit (CIT), a dangerous condition where a blood clot lodges in the right heart, requires prompt management. This case study highlights successful medical treatment for CIT, a rare but life-threatening venous thromboembolism.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Critical Care Medicine

Background:

  • Clot in transit (CIT) is a rare but life-threatening condition involving venous thromboembolism lodged in the right heart.
  • CIT occurs in up to 18% of massive pulmonary embolism cases, with untreated mortality rates of 80-100%.

Purpose of the Study:

  • To present a case of Clot in Transit (CIT) successfully treated with medical management.
  • To emphasize the critical need for prompt identification and management of CIT due to high mortality.

Main Methods:

  • Case report of a 44-year-old female patient diagnosed with CIT.
  • Treatment focused on medical management strategies.

Main Results:

  • Successful treatment of CIT was achieved through medical management.
  • The case underscores the importance of recognizing and intervening in CIT.

Conclusions:

  • Clot in transit (CIT) is a critical medical emergency requiring immediate attention.
  • Risk factors for CIT include heart failure, central venous catheters, and recent hospitalization.
  • Emerging interventions offer new hope for CIT treatment.

Keywords:
Clot in transitpulmonary embolismthrombectomyvenous thromboembolism

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