Numerical and morphological analysis of human endocervical cells in relation to peripheral estrogen levels

To verify a previous hypothesis in the literature, a quantitative analysis of the endocervical muciparous cells was performed together with a histological and cytological study of the endocervical crypts and their muciparous cells, in relation to the variability of peripheral estrogen levels. Twenty healthy human cervices were studied. From the statistical analysis of the data obtained counting muciparous cells of the crypts of each with a different ovarian hormone pattern, a high significance emerged, excluding an individual biological variability of the subjects on the changes in cell number. This demonstrates that numerical variability of the endocervical muciparous cells is related to ovarian hormone variability. However, as morphological observations reveal that estrogens regulate the in-decreasing of the endocervical cells, a relation between numerical variability of endocervical cells and blood estrogen levels is deduced.