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Renal and liver function tests in surgical septicemia.

N Smith-Erichsen

    Acta Anaesthesiologica Scandinavica
    |April 1, 1987
    PubMed
    Summary

    Renal function tests, particularly creatinine clearance, effectively predict outcomes in surgical septicemia and septic shock. Liver function tests showed limited prognostic value for septicemia survival.

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    Intensive care medicine·1997

    Area of Science:

    • Nephrology
    • Critical Care Medicine
    • Hepatology

    Background:

    • Sepsis, a life-threatening organ dysfunction caused by dysregulated host response to infection, remains a significant challenge in critical care.
    • Identifying reliable prognostic markers for surgical septicemia and its complication, septic shock, is crucial for timely intervention and improved patient outcomes.

    Purpose of the Study:

    • To evaluate the prognostic value of conventional renal and liver function tests in patients with surgical septicemia.
    • To determine the sensitivity of specific renal and liver function parameters in predicting the outcome of septic shock.

    Main Methods:

    • Prospective evaluation of renal function variables (serum creatinine, creatinine clearance, urine output) and liver function tests (serum albumin, total protein) in patients with surgical septicemia.
    • Comparison of test results between patients who developed septic shock and those who did not, and between fatal and non-fatal outcomes.

    Main Results:

    • Changes in renal function variables were associated with septic shock development. Creatinine clearance was the most sensitive predictor of septic shock outcome.
    • Significantly lower creatinine clearance and urine output, and higher serum creatinine concentrations were observed in fatal septic shock cases.
    • Renal function remained normal in septicemia without shock, irrespective of outcome. Serum albumin and total protein showed minor differences between survivors and non-survivors in persistent septicemia, with limited predictive value.

    Conclusions:

    • Creatinine clearance is a sensitive prognostic indicator for septic shock in surgical septicemia.
    • Conventional renal function tests, especially creatinine clearance, offer valuable prognostic insights into septicemia and septic shock outcomes.
    • Liver function tests, including serum albumin and total protein, have limited utility in predicting septicemia outcomes in this study.

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