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07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
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Therapy for contact lens-related ulcers
1Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.
Current Opinion in Ophthalmology
|July 2, 2022
Summary
Antimicrobial therapy for contact lens-related microbial keratitis (CLMK) faces challenges with fungal and acanthamoeba infections. New treatments are being developed to combat antibiotic resistance and improve outcomes for this vision-threatening condition.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Contact lens-related microbial keratitis (CLMK) is a significant cause of vision loss.
- Bacterial infections are most common, but fungal and acanthamoeba keratitis are challenging to treat.
- Limited topical medication options and low efficacy of current therapies contribute to treatment difficulties.
Purpose of the Study:
- To review current literature and practice patterns for antimicrobial therapy in CLMK.
- To highlight challenges in treating fungal and acanthamoeba keratitis.
- To discuss emerging and novel therapeutic approaches.
Main Methods:
- Literature review of antimicrobial therapy for CLMK.
- Analysis of current treatment strategies for bacterial, fungal, and acanthamoeba keratitis.
- Evaluation of antibiotic resistance patterns and novel treatment modalities.
Main Results:
- Topical antimicrobials are the primary treatment for corneal ulcers.
- Fluoroquinolones can be used for small bacterial ulcers, but antibiotic resistance is a concern.
- Fungal and acanthamoeba keratitis are less responsive to conventional therapy, requiring adjunct oral/intrastromal antifungals or newer agents.
Conclusions:
- CLMK is a serious condition with potential for vision loss.
- Effective treatment remains challenging, particularly for non-bacterial forms.
- Promising new diagnostics and therapies are under development, offering hope for improved patient outcomes.
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