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Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

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Corneal Epithelial Defects in Diabetic Patients Following Pars Plana Vitrectomy.

Kristin Ates Hicks¹, Yujia Zhou¹, Jay Talati²

¹Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.

Journal of Ophthalmology

|May 2, 2025

Summary

Diabetes increases the risk of corneal epithelial defects (CEDs) after pars plana vitrectomy (PPV). While overall risk is similar between nonproliferative and proliferative diabetic retinopathy, PDR patients may experience more persistent defects.

Keywords:

corneal epithelial defect diabetes mellitus pars plana vitrectomy

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Published on: November 22, 2024

Area of Science:

Ophthalmology
Diabetology
Retinal Surgery

Background:

Diabetes mellitus is a known risk factor for corneal epithelial defects (CEDs) following pars plana vitrectomy (PPV).
The impact of diabetes severity and specific risk factors on CED development and healing post-PPV remains unclear.

Purpose of the Study:

To identify factors associated with CED and healing time in diabetic patients undergoing PPV.
To investigate the relationship between diabetes severity and postoperative CED risk and duration.

Main Methods:

Retrospective cohort study of patients undergoing PPV for retinal detachment (RD).
Analysis of electronic health records for diabetes type, duration, severity, and comorbidities.
Outcomes included CED presence, treatment, and healing time within one month postoperatively.

Main Results:

Diabetes was significantly associated with the development of initial CED post-PPV (p=0.040).
No significant difference in CED risk was found between nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) groups.
PDR patients showed a trend towards more severe long-term outcomes, including persistent corneal epithelial defects (PCEDs).

Conclusions:

Diabetic patients are at increased risk for CED after PPV.
While initial CED risk may not differ significantly between NPDR and PDR, PDR patients warrant closer monitoring for potential persistent defects and may benefit from earlier intervention.