Related Experiment Video
Updated: Sep 6, 2025
10:46
Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
Published on: September 17, 2014
15.4K
Descemet membrane endothelial keratoplasty in complex eyes
Aazim Siddiqui1, Winston D Chamberlain
1Division of Cornea and Refractive Surgery, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Current Opinion in Ophthalmology
|July 2, 2022
Summary
Descemet membrane endothelial keratoplasty (DMEK) is feasible in complex eyes, but presents significant surgical challenges. Further standardization and prospective data are needed to clarify its long-term role in corneal rehabilitation.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Regenerative Medicine
Background:
- Descemet membrane endothelial keratoplasty (DMEK) is a standard procedure for Fuchs endothelial dystrophy and simple bullous keratopathy.
- Complex ocular conditions present unique challenges for DMEK surgery, including poor visualization and altered anterior segment anatomy.
Purpose of the Study:
- To review the current literature on the application of DMEK in complex eyes.
- To identify challenges and variations in techniques for DMEK in complex ocular cases.
Main Methods:
- Literature review of studies reporting DMEK in complex eyes.
- Analysis of intraoperative and postoperative challenges and outcomes.
Main Results:
- DMEK is feasible in complex eyes, such as those with advanced bullous keratopathy, glaucoma, uveitis, or prior surgeries.
- Techniques for DMEK in complex eyes vary widely, lacking standardization.
- Outcomes highlight surgical difficulty and uncertainty in long-term graft survival.
Conclusions:
- DMEK can be performed in a variety of complex ocular conditions.
- Standardization of surgical techniques and prospective studies are crucial.
- Further research is needed to establish the long-term efficacy and role of DMEK in complex eyes.
