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Correlation Between Proteolytic Activity and Abdominal Aortic Aneurysm Wall Morphology with Intraluminal Thrombus
Milos Sladojevic1, Igor Koncar1, Petar Zlatanovic2
1Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for Vascular and Endovascular Surgery, Clinical Center of Serbia, Belgrade, Serbia.
Annals of Vascular Surgery
|July 2, 2022
Summary
Intraluminal thrombus (ILT) volume in abdominal aortic aneurysms (AAAs) did not significantly impact proteolytic activity or wall content. However, increased ILT volume correlated positively with catalase activity in the AAA wall.
Area of Science:
- Vascular Surgery
- Biochemistry
- Pathology
Background:
- Abdominal aortic aneurysm (AAA) is a life-threatening condition.
- Intraluminal thrombus (ILT) is a common feature within AAAs.
- The relationship between ILT volume and AAA wall composition remains unclear.
Purpose of the Study:
- To investigate the influence of intraluminal thrombus (ILT) volume on proteolytic activity.
- To assess the impact of ILT volume on the biochemical content of the abdominal aortic aneurysm (AAA) wall.
Main Methods:
- Cross-sectional study involving 50 patients with asymptomatic AAA undergoing open surgical repair.
- Pre-operative MRI to assess ILT volume.
- Biochemical analysis of ILT and AAA wall samples for proteolytic enzymes and extracellular matrix proteins.
Main Results:
- A significant correlation was observed between ILT volume and the largest AAA diameter (ρ=0.56, P<0.001).
- No significant correlation was found between ILT volume and MMP-9, MMP-2, NE/ELA, or ECM protein concentrations in the AAA wall.
- A positive correlation was identified between ILT volume and catalase activity in the AAA wall (ρ=0.28, P=0.049).
Conclusions:
- ILT volume does not appear to significantly influence proteolytic activity or the general content of the AAA wall.
- A notable positive correlation exists between ILT volume and catalase activity within the AAA wall.
- Further research is warranted to elucidate the role of ILT in AAA progression.
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