Development of an EQ-5D Value Set for India Using an Extended Design (DEVINE) Study: The Indian 5-Level Version EQ-5D...

Area of Science:

• Health Economics
• Psychometrics
• Public Health

Background:

• The EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) instrument is crucial for health technology assessment (HTA).
• Developing a country-specific EQ-5D-5L value set is essential for accurate HTA and resource allocation.
• India previously lacked a comprehensive EQ-5D-5L value set.

Purpose of the Study:

• To develop the Indian 5-level version EQ-5D (EQ-5D-5L) value set.
• To provide a key input for health technology assessment (HTA) and healthcare resource allocation in India.

Main Methods:

• A cross-sectional survey of 3548 adult respondents across 5 Indian states.
• Utilized a novel extended EuroQol Group's Valuation Technology with composite time trade-off (c-TTO) and discrete choice experiment (DCE) tasks.
• Employed a hybrid modeling approach combining c-TTO and DCE data for value set estimation.

Main Results:

• Analysis included 2409 interviews.
• A hybrid heteroscedastic model integrating c-TTO and DCE data produced the most consistent results.
• Predicted values for 3125 health states ranged from -0.923 to 1, with pain/discomfort being the most influential dimension.

Conclusions:

• This is the largest EQ-5D-5L valuation study globally to date.
• The developed Indian EQ-5D-5L value set will enhance HTA studies in India.
• It will generate credible evidence for efficient healthcare resource utilization.