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Transcription factor EB controls both motogenic and mitogenic cell activities
Elena Astanina1,2, Federico Bussolino1,2, Gabriella Doronzo1,2
1Department of Oncology, University of Torino, Italy.
FEBS Letters
|July 5, 2022
Summary
Transcription factor EB (TFEB) is an oncogene involved in cellular stress responses. Emerging research reveals its broader roles in cell proliferation and motility, impacting various diseases.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Transcription factor EB (TFEB) is a member of the microphthalmia family of transcription factors.
- Initially identified as an oncogene in renal cell carcinoma, TFEB regulates cellular stress responses.
- Its known functions include lysosome biogenesis, autophagy, and metabolic modulation.
Purpose of the Study:
- To review the emerging roles of TFEB in cellular proliferation and motility.
- To highlight TFEB's broader functions beyond stress response.
- To underscore TFEB's significance in various disease pathways.
Main Methods:
- Literature review of recent findings on TFEB.
- Analysis of TFEB's involvement in cellular processes.
- Synthesis of TFEB's role in disease pathogenesis.
Main Results:
- TFEB plays a significant role in regulating cellular proliferation.
- TFEB influences cellular motility, a key factor in cancer metastasis.
- TFEB's functions extend to tissue generation and immune responses.
Conclusions:
- TFEB acts as a central hub in signaling networks.
- TFEB is implicated in non-communicable diseases including cancer and ischemic diseases.
- Understanding TFEB's diverse roles is crucial for therapeutic strategies in various diseases and tissue regeneration.
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