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Updated: Sep 6, 2025
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Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
Anouk M La Rose1, Anouk G Groenen1, Benedek Halmos1
1Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Molecular Genetics and Metabolism Reports
|July 5, 2022
Abstract:
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
Keywords:
AtherosclerosisG6P, Glucose-6-phosphateG6PC1, Glucose-6-phosphatase enzymeGSD Ia, Glycogen storage disease type 1aGlycogen storage disease type 1aHDL, High-density lipoproteinHyperlipidemiaLdlr−/−, LDL receptor deficientPUFA, Poly-unsaturated FASFA, Saturated fatty acidsTG, TriglyceridesVLDL, Very-low-density lipoproteinWTD, Western-type diet
