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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

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Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
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Associations Between Plasma Lipoprotein(a) Levels and Circulating Monocyte Subsets Differ across Populations.

Alexander C Bashore, Benedek Halmos, Anastasiya Matveyenko

    Biorxiv : the Preprint Server for Biology
    |June 12, 2026
    PubMed
    Summary

    Lipoprotein(a) [Lp(a)] levels and oxidized phospholipids (oxPL) impact monocyte subsets differently based on race. These findings emphasize race as a crucial factor in studying Lp(a)-related cardiovascular disease risk.

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    Last Updated: Jun 13, 2026

    Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
    09:41

    Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

    Published on: October 17, 2017

    Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis
    09:12

    Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis

    Published on: October 17, 2018

    Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro
    09:16

    Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

    Published on: November 26, 2018

    Area of Science:

    • Cardiovascular Research
    • Immunology
    • Genetics

    Background:

    • Lipoprotein(a) [Lp(a)] is a known cardiovascular disease (CVD) risk factor, with higher plasma concentrations typically observed in Black individuals compared to White individuals.
    • Elevated Lp(a) and its associated oxidized phospholipids (oxPL) may promote arterial inflammation by influencing monocyte phenotypes.

    Purpose of the Study:

    • To investigate the associations between Lp(a) levels, apo(a) isoform size, and circulating monocyte populations in Black and White individuals.
    • To explore the role of race in modifying these associations using single-cell RNA sequencing (scRNA-seq).

    Main Methods:

    • Plasma Lp(a), apo(a) isoform size, inflammatory markers, and oxPL were measured in a cohort of 34 participants (20 Black, 14 White) after exclusions.
    • Multivariable linear regression and scRNA-seq were used to analyze associations between Lp(a), oxPL, and monocyte subset proportions.
    • Participants were stratified into normal and high Lp(a) groups.

    Main Results:

    • Monocyte subset distributions did not significantly differ between normal and high Lp(a) groups.
    • Race significantly modified the association between plasma Lp(a) levels and non-classical monocyte abundance, showing an inverse association in White participants but not in Black participants.
    • OxPL bound to apo(a) correlated strongly with plasma Lp(a) and exhibited race-dependent associations with non-classical monocytes and classical 2 monocytes.

    Conclusions:

    • The relationship between Lp(a), oxPL, and circulating monocyte subsets is race-dependent.
    • Self-reported race is an important consideration in research examining Lp(a)-related immune responses and cardiovascular phenotypes.