Crosstalk Between Histone and m⁶A Modifications and Emerging Roles of m⁶A RNA Methylation

RNA, like DNA and proteins, has been discovered to undergo dynamic and reversible chemical alterations, increasing the diversity and functional complexity of the molecule. N-6-methyladenosine (m⁶A) RNA methylation serves as a bridge between transcription and translation and is critical for many diseases' progression. There is a complex interrelationship between m⁶A modifications and other epigenetic modifications. Their crosstalk significantly affects transcriptional outputs, translation, recruitment of chromatin modifiers, as well as the deployment of the m⁶A methyltransferase complex at target sites. This article outlines the potential function of m⁶A RNA methylation in epigenetics and summarizes its interactions with histone modifications.