Medical reversal of acquired hypophosphatemic osteomalacia

Hypophosphatemic osteomalacia may present as severe disability from bone disease. This report describes a patient with long-standing disease and multiple fractures. Medical management of the phosphate loss may be successful in promoting bone healing when it is not possible to establish the cause of the phosphaturia. Judicious increases in calcium, 1,25-dihydroxyvitamin D, and phosphorus supplements were carefully monitored to avoid failure of therapy or hypercalcemic complications from pharmacologic amounts of these supplements.