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Cell-Free Blood Cell Secretome (BCS) Counteracts Skin Aging: Multi-Center Prospective Regenerative Aesthetic Medicine
Martina Kerscher1, Sylvia Wagner-Schiffler2, Ernst Magnus Noah3
1Division of Cosmetic Sciences, University of Hamburg, Hamburg, Germany.
Clinical, Cosmetic and Investigational Dermatology
|July 5, 2022
Summary
Cell-free blood cell secretome (BCS) injections improved facial skin firmness and resilience in women. Patients reported increased satisfaction and perceived a younger appearance, indicating BCS
Area of Science:
- Dermatology and Regenerative Medicine
- Cellular Biology and Aging Research
Background:
- The Inflammation Theory of Ageing posits that pro-inflammatory cytokines and oxidative damage contribute to cellular aging.
- Cell-free blood cell secretome (BCS), also known as autologous conditioned serum (ACS), exhibits anti-inflammatory and regenerative properties, with demonstrated efficacy in musculoskeletal and radicular conditions.
Observation:
- A multi-center study evaluated BCS for improving signs of skin aging.
- Ninety-five women with age-related facial skin laxity received four intra-dermal BCS injections over six weeks.
- Cutometric measurements (R0, R3), Global Aesthetic Improvement Scale (GAIS), FACE-Q™ questionnaires, and safety assessments were conducted.
Findings:
- Significant improvements in skin firmness (R0) and resilience to tiring (R3) were observed at 12 and 24 weeks post-treatment.
- Patient-reported outcomes showed significant enhancements in "Satisfaction with Skin" and "Satisfaction with Facial Appearance" up to 48 weeks.
- Patients perceived their facial appearance as 1.68 years younger, with improved aging appraisal scores.
Implications:
- BCS injections effectively enhance facial skin firmness, resilience, and patient satisfaction.
- The treatment demonstrates a sustainable rejuvenating effect on facial skin.
- BCS offers a safe and effective therapeutic option for mitigating visible signs of skin aging.
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