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Correlation of Blood Lipid and Serum Inflammatory Factor Levels With Hypertensive Disorder Complicating Pregnancy

Wangxiang Chen1, Yan Guo2, Xia Yao1

  • 1Department of obstetrics, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, China.

Frontiers in Surgery
|July 5, 2022
PubMed

Insights

Hypertensive disorder complicating pregnancy (HDP) is linked to altered blood lipid and inflammatory markers. These factors, including total cholesterol and C-reactive protein, show predictive value for HDP development and progression.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Health
  • Immunology

Background:

  • Hypertensive disorder complicating pregnancy (HDP) poses significant risks to maternal and fetal health.
  • Understanding the biochemical markers associated with HDP is crucial for early detection and management.

Purpose of the Study:

  • To investigate the relationship between blood lipid profiles and serum inflammatory factors in pregnant women with HDP.
  • To assess the predictive value of these markers for the development and progression of HDP.

Main Methods:

  • A cohort of 107 pregnant women with HDP and 30 healthy pregnant women were analyzed.
  • Serum levels of total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, Lp-PLA2, CRP, IL-6, and TNF-α were measured.
  • Receiver operating characteristic (ROC) curve analysis was employed to evaluate predictive values.

Main Results:

  • Serum TC, TG, and LDL-C levels increased, while HDL-C levels decreased with HDP severity.
  • Serum Lp-PLA2, CRP, IL-6, and TNF-α levels were elevated in HDP patients and increased with disease progression.
  • High area under the curve (AUC) values were observed for inflammatory markers (e.g., CRP, TNF-α) and lipid profiles in predicting HDP.

Conclusions:

  • Blood lipid profiles and serum inflammatory factors are significantly altered in HDP.
  • These markers demonstrate considerable potential for predicting the occurrence and progression of HDP.
Abstract

Keywords:
blood lipidhypertensive disorder complicating pregnancyinflammatory factorspredictive valuepreeclampsia

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