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Updated: Sep 5, 2025

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Published on: May 8, 2018

Functional Liver Imaging in Radiotherapy for Liver Cancer: A Systematic Review and Meta-Analysis.

Pi-Xiao Zhou¹, Ying Zhang¹, Quan-Bin Zhang¹

¹Radiotherapy Center, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.

Frontiers in Oncology

|July 5, 2022

Summary

Functional liver-sparing radiotherapy planning shows promise in reducing radiation dose to the liver and lowering the risk of radiation-induced liver disease (RILD). Further research is needed to confirm these benefits in clinical trials.

Keywords:

dose-response functional liver imaging liver neoplasms radiation-induced liver toxicity (RILT)radiotherapy

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Area of Science:

Radiotherapy
Medical Imaging
Hepatology

Background:

Functional liver imaging identifies heterogeneity in liver distribution, crucial for radiotherapy planning.
The clinical feasibility and benefits of functional liver-sparing radiotherapy planning remain largely unknown.

Approach:

A comprehensive literature search identified 20 publications for meta-analysis.
Evaluated dosimetric and clinical benefits of functional liver-sparing radiotherapy.
Assessed functional imaging's ability to predict radiation-induced liver toxicity (RILT) and dose-response relationships.

Key Points:

Meta-analysis showed reduced mean functional liver dose (f-MLD) and functional liver volume receiving ≥20 Gy (fV20) with liver-sparing planning.
Prospective studies reported low incidence of radiation-induced liver damage (RILD) with this approach.
Functional imaging proved superior to CT in predicting RILT.

Conclusions:

Despite heterogeneous methods, functional liver imaging integration into radiotherapy offers potential clinical benefits for liver cancer patients.
Randomized clinical trials are necessary for future validation of these findings.