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Related Experiment Video

Updated: Sep 5, 2025

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

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Published on: February 16, 2022

Nitric-Oxide-Modulatory Materials for Biomedical Applications.

Taejeong Kim¹, Yunyoung Nah¹, Jeonghyun Kim¹

¹Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 37673, Republic of Korea.

Accounts of Chemical Research

|July 5, 2022

Summary

Researchers developed advanced nitric oxide (NO) modulatory materials using polymers and hybrids to control NO levels in the body. These novel materials aim for precise NO delivery or scavenging, overcoming limitations of current therapies for better clinical translation.

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En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

Published on: February 25, 2016

Area of Science:

Biomedical Engineering
Materials Science
Pharmacology

Background:

Nitric oxide (NO) is a crucial signaling molecule with dual roles in cell proliferation and apoptosis, dependent on concentration.
Precise control over NO levels in vivo is vital for therapeutic applications but challenging due to stability and specificity issues.
Existing NO donors and scavengers face limitations in bioavailability and targeted action.

Purpose of the Study:

To review and discuss strategies for designing next-generation NO-modulatory materials.
To highlight advancements in controlling NO concentrations for biomedical applications.
To address challenges and outline future directions for therapeutic development of NO-modulatory systems.

Main Methods:

Development of polymeric, inorganic, and hybrid materials for NO modulation.
Chemical encapsulation of NO donors within stimuli-responsive vehicles.
Strategies for selective NO scavenging at inflammatory sites.

Main Results:

Engineered materials enhance the bioavailability of NO donors/scavengers.
On-demand NO release achieved through encapsulated systems.
Demonstrated potential for targeted NO depletion in inflammatory conditions.

Conclusions:

Rational design of NO-modulatory materials is key for therapeutic advancement.
Overcoming current challenges will enable clinical translation of NO-based therapies.
These materials offer a promising platform for revolutionizing future therapeutics.