Related Experiment Video
Updated: Sep 5, 2025
11:57
Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
Published on: February 24, 2021
10.5K
Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice
Summary
Ultrasound deep brain stimulation (UDBS) of the hypothalamus can noninvasively regulate body temperature in mice. This neuromodulation technique shows promise for treating temperature-related disorders like hyperthermia and hypothermia.
Area of Science:
- Neuroscience
- Thermoregulation
- Neuromodulation
Background:
- Body temperature is crucial for sensorimotor recovery in brain diseases like stroke.
- The hypothalamus is central to the body's thermoregulation processes.
- Ultrasound deep brain stimulation (UDBS) offers a noninvasive method to modulate brain activity.
Purpose of the Study:
- To investigate the potential of UDBS targeting the hypothalamus for regulating body temperature in free-moving mice.
- To explore the relationship between ultrasonic parameters and thermoregulation effects.
Main Methods:
- Utilized UDBS to stimulate specific hypothalamic regions (preoptic area and dorsomedial hypothalamus) in mice.
- Varied ultrasonic parameters such as pulse repetition frequency (PRF), duty cycle, total time, and acoustic pressure.
- Monitored changes in body temperature following stimulation.
Main Results:
- Thermoregulation was significantly influenced by UDBS parameters.
- Stimulation of the anterior hypothalamus (500 Hz PRF) decreased body temperature.
- Stimulation of the dorsomedial hypothalamus (10 Hz PRF) increased body temperature.
Conclusions:
- UDBS can effectively modulate hypothalamic thermoregulation in a noninvasive manner.
- This technique holds potential for future clinical applications in treating conditions like malignant hyperthermia and hypothermia.
