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[Amino acids in cerebrospinal fluid. Reference values].

M A Gelot

    Annales De Biologie Clinique
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    This study establishes reference values for 28 amino acids in cerebrospinal fluid (CSF) using literature data from 453 patients. Separate reference ranges are provided for children under and over two years old, and for adults.

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    Area of Science:

    • Clinical Chemistry
    • Neuroscience
    • Biochemistry

    Background:

    • Cerebrospinal fluid (CSF) amino acid profiles are crucial biomarkers.
    • Establishing reliable reference values is essential for diagnosing neurological and metabolic disorders.

    Purpose of the Study:

    • To determine reference values for 28 amino acids in human cerebrospinal fluid.
    • To provide age-specific reference ranges for pediatric and adult populations.

    Main Methods:

    • Systematic literature review to collect existing amino acid dosage data in CSF.
    • Analysis of data from 453 adult and pediatric patients.
    • Development of two distinct reference value series based on age.

    Main Results:

    Related Experiment Videos

  • Compilation of reference values for 28 distinct amino acids in CSF.
  • Identification of two age-based reference value sets: one for children under 2 years, and another for children over 2 years and adults.
  • Comprehensive dataset derived from a significant patient cohort.

    • Conclusions:

    • The study provides essential reference data for cerebrospinal fluid amino acid analysis.
    • Age-stratified reference values enhance the clinical utility of CSF amino acid profiling.
    • This resource aids in the interpretation of patient results and the diagnosis of associated conditions.