Jove
Visualize
Contact Us

Related Experiment Videos

Automatic control of anesthesia using two feedback variables.

G F Schils, F J Sasse, V C Rideout

    Annals of Biomedical Engineering
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Experimental use of iteratively designed rotation invariant correlation filters.

    Applied optics·2010
    Same author

    Iterative technique for the synthesis of distortion-invariant optical correlation filters.

    Optics letters·2009
    Same author

    Model for the administration of low-flow anaesthesia.

    British journal of anaesthesia·1998
    Same author

    The response of anesthetic agent monitors to trifluoromethane warns of the presence of carbon monoxide from anesthetic breakdown.

    Journal of clinical monitoring·1997
    Same author

    A first course in computer-aided physiological modeling.

    Biomedical sciences instrumentation·1991
    Same author

    A non-pulsatile multiple model for pharmacokinetics simulation.

    Biomedical sciences instrumentation·1988
    Same journal

    Patient-Specific Adaptation of a Mechano-Regulatory Bone-Healing Model Using Longitudinal Loading Data.

    Annals of biomedical engineering·2026
    Same journal

    Effects of Simulated Body-Mass Reduction on Peak Knee Joint Loads During Daily Functional Activities.

    Annals of biomedical engineering·2026
    Same journal

    Evaluating Different Optimization Criteria for Estimating Spine Loads and Muscle Activity During Manual Lifting With and Without Assistance from Back-Support Exoskeletons.

    Annals of biomedical engineering·2026
    Same journal

    A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.

    Annals of biomedical engineering·2026
    Same journal

    Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.

    Annals of biomedical engineering·2026
    Same journal

    A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.

    Annals of biomedical engineering·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    A novel ON/OFF controller for halothane anesthesia offers improved robustness and faster response times compared to traditional methods. This new system effectively manages anesthetic depth using mean arterial blood pressure and EEG frequency.

    Area of Science:

    • Anesthesiology
    • Control Engineering
    • Biomedical Engineering

    Background:

    • Anesthesia delivery requires precise control of anesthetic agents like halothane.
    • Existing proportional-plus-integral controllers with time-delay compensation lack robustness in clinical settings.
    • Anesthetic agents affect multiple physiological variables, complicating control.

    Purpose of the Study:

    • To develop and evaluate a robust ON/OFF controller for halothane anesthesia.
    • To implement a control strategy for managing multiple physiological effects of anesthetics.
    • To compare the performance of an ON/OFF controller against a proportional-plus-integral controller.

    Main Methods:

    • Computer simulations and animal trials were used to assess controller performance.

    Related Experiment Videos

  • An ON/OFF controller was designed and implemented for halothane administration.
  • Mean arterial blood pressure and electroencephalogram (EEG) frequency were selected as controlled variables.
  • A coordinator was developed to manage system state towards desired variable values.

    • Main Results:

    • The ON/OFF controller demonstrated superior robustness to parameter mismatches compared to the proportional-plus-integral controller.
    • Animal trials confirmed a short response time and acceptable steady-state tracking with the ON/OFF controller.
    • The developed method effectively switched the controlled effects of halothane.

    Conclusions:

    • The ON/OFF controller is a robust and effective alternative for halothane anesthesia delivery.
    • This control strategy can manage multiple physiological effects of anesthetics using key variables.
    • The findings support the clinical applicability of advanced control systems in anesthesia.