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Related Experiment Video

Updated: Jul 6, 2026

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training
09:57

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Published on: January 18, 2021

A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.

Moritz Wiegand1,2, Lukas Obermeier3,4, Hannes Dillinger5

  • 1Deutsches Herzzentrum der Charité, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany. moritz.wiegand@dhzc-charite.de.

Annals of Biomedical Engineering
|July 5, 2026
PubMed
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A novel MRI-compatible left ventricle (LV) phantom was developed to overcome limitations in cardiac MRI and CFD simulation validation. This phantom reproduces realistic cardiac motion and flow, enabling robust data generation for high-fidelity model development.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Computational Fluid Dynamics

Background:

  • In vivo validation of cardiac MRI and CFD simulations is hindered by scan time and motion artifacts.
  • Accurate modeling of intracardiac hemodynamics requires robust, reproducible data.
  • Existing phantoms often lack realistic cardiac motion and anatomical detail.

Purpose of the Study:

  • To develop a subject-specific, MRI-compatible left ventricle (LV) phantom for validating cardiac MRI and CFD simulations.
  • To create a phantom capable of reproducing cardiac motion and physiological flow patterns.
  • To provide a stable platform for generating high-fidelity data for model development.

Main Methods:

  • Fabricated a left ventricle (LV) phantom from PVA-based hydrogel for MRI contrast, stability, and reusability.
Keywords:
Cardiac MRIComputational fluid dynamicsImage-based modelingMock circulatory loopPhantom modelVerification

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Last Updated: Jul 6, 2026

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training
09:57

Development and Evaluation of 3D-Printed Cardiovascular Phantoms for Interventional Planning and Training

Published on: January 18, 2021

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
11:16

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging

Published on: February 25, 2022

Blood Flow Imaging with Ultrafast Doppler
05:57

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Published on: October 14, 2020

  • Integrated aortic and mitral valves to approximate physiological opening and closing.
  • Utilized a closed-loop circulation system with an MRI-safe pump to reproduce cardiac motion and flow.

    • Main Results:

    • The LV phantom accurately replicated healthy end-diastolic and end-systolic geometries with physiological contraction.
    • 4D flow MRI confirmed realistic intracardiac flow patterns, including vortex ring formation and systolic outflow.
    • The phantom enabled CFD simulations incorporating LV and valve motion, demonstrating its utility for in vitro validation.

    Conclusions:

    • The developed LV phantom offers a stable, MRI-compatible platform for generating reproducible data to validate intracardiac hemodynamic models.
    • The phantom's realistic anatomy, motion, and flow support both simulation validation and MRI sequence development.
    • Future work will refine valve kinematics and LV motion fidelity for enhanced realism.