Patient Preference Studies for Advanced Prostate Cancer Treatment Along the Medical Product Life Cycle: Systematic...

Area of Science:

• Oncology
• Health Services Research
• Patient-Reported Outcomes

Background:

• The treatment landscape for advanced prostate cancer (APC) has evolved significantly.
• Key patient-relevant aspects of APC treatments remain poorly understood.
• Patient preference studies are crucial for informing decisions throughout the medical product life cycle (MPLC).

Purpose of the Study:

• To systematically review patient preference studies in APC.
• To summarize evidence on patient preferences and relevant treatment aspects.
• To evaluate the contribution of these studies to MPLC decision-making.

Main Methods:

• Systematic literature search of MEDLINE and EMBASE up to October 2020.
• Independent screening, data extraction, and quality assessment by two reviewers.
• Descriptive summary of findings and analysis using an MPLC framework.

Main Results:

• Seven quantitative preference studies were included, with varied MPLC stage distribution.
• Stated aims to inform clinical practice were common, but specific contributions were often unclear.
• Relative importance of treatment benefits, harms, and other aspects varied; high overall quality but with methodological limitations.

Conclusions:

• Patient-relevant aspects of APC benefits and harms are not yet established.
• It remains unclear which APC treatments are preferred by patients.
• Future patient preference studies should utilize the MPLC framework for clearer aims and design, with transparent reporting.