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Published on: November 20, 2015
Association of early cerebral oxygen saturation and brain injury in extremely preterm infants
Mohamed El-Dib1,2, Chelsea Munster3, John Sunwoo4,5
1Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA. mel-dib@bwh.harvard.edu.
Objective:
To assess the association between cerebral saturation (crSO2) using Near-Infrared Spectroscopy (NIRS) and brain injury in extremely preterm infants.
Study Design:
This retrospective study includes 62 infants (<28 weeks gestation) who underwent continuous NIRS monitoring in the first 5 days after birth. Median crSO2 were compared in 12 h increments between infants with and without germinal matrix/intraventricular hemorrhage (GM/IVH). crSO2 was also compared by IVH severity, onset, and by grade of injury on term equivalent MRI.
Results:
After 48 h of life (HOL), infants with GM/IVH had significantly lower crSO2 than those without GM/IVH in analysis adjusted for potential confounding e.g., at 49-60 HOL (69.5 (66.2, 72.8) vs. 74.7 (71.8, 77.6), p = 0.023). There were no significant differences in crSO2 by IVH subcategory or injury severity on MRI.
Conclusion:
Clinical use of NIRS has the potential to identify crSO2 patterns associated with development of GM/IVH.
