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Crouzon syndrome and the eye: An overview
Kasturi Bhattacharjee1, Obaidur Rehman1, Vatsalya Venkatraman1
1Department of Orbit, Oculoplasty and Facial Aesthetics, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.
Indian Journal of Ophthalmology
|July 6, 2022
Summary
Crouzon syndrome, a common craniosynostosis, causes craniofacial and orbital abnormalities. This review details ocular findings and emphasizes a multidisciplinary approach for managing these ophthalmic features.
Area of Science:
- Ophthalmology
- Genetics
- Craniofacial Surgery
Background:
- Crouzon syndrome is the most frequent craniosynostosis, characterized by premature skull suture fusion.
- This fusion leads to significant craniofacial anomalies, particularly affecting the orbits and ocular structures.
Purpose of the Study:
- To comprehensively review and evaluate the ocular findings and associated ophthalmic features in patients with Crouzon syndrome.
- To synthesize current literature on the ophthalmic manifestations of this condition.
Main Methods:
- An extensive literature search was conducted using PubMed, Scopus, Cochrane Library, and Ovid.
- Key search terms included "Crouzon", "craniosynostosis", "eye", and "ophthalmic".
- A total of 42 articles were included after initial screening and augmented searches.
Main Results:
- The review details a wide range of associated ophthalmic anomalies in Crouzon syndrome.
- Specific surgical techniques for managing conditions like bilateral luxation bulbi with exposure keratopathy are discussed.
- Craniofacial and oculo-facial dysmorphisms require specialized management strategies.
Conclusions:
- Ocular findings are a significant component of Crouzon syndrome's clinical presentation.
- Optimal management necessitates a collaborative, multidisciplinary team of specialists.
- Further research into surgical and non-surgical interventions is warranted.
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