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Docetaxel-induced Flagellate Erythema - Case Report and Brief Review
Jerbi Asma1,2, Kastalli Sarrah1,2, Charfi Ons1,2
1National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia.
Current Drug Safety
|July 7, 2022
Summary
Flagellate erythema is a rare skin reaction that can occur with docetaxel chemotherapy. This case report details a patient who experienced this reaction, highlighting the need for further research into its mechanisms and management.
Area of Science:
- Dermatology
- Oncology
- Clinical Medicine
Background:
- Flagellate erythema is a distinct skin reaction characterized by whiplash-like, pruritic, erythematous eruptions.
- While commonly associated with bleomycin, it is rarely reported with docetaxel.
- This case adds to the limited literature on docetaxel-induced flagellate erythema.
Approach:
- This report details a rare case of flagellate erythema in a 53-year-old woman undergoing docetaxel treatment for metastatic breast cancer.
- The patient developed characteristic linear, pruritic erythematous streaks on her chest and abdomen.
- The reaction recurred with subsequent docetaxel courses, confirming the association.
Key Points:
- The patient presented with a pruritic, linear erythematous eruption consistent with flagellate erythema.
- The skin reaction appeared after docetaxel administration and resolved spontaneously.
- Post-inflammatory hyperpigmented linear scars were noted after the eruption subsided.
Conclusions:
- Flagellate erythema is a documented adverse drug reaction to various antineoplastic agents, including docetaxel.
- Understanding the underlying mechanisms of docetaxel-induced flagellate erythema is crucial for developing effective treatment and prevention strategies.
- Further research is warranted to elucidate the pathophysiology and optimize patient care for this condition.
