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Facial Hyperpigmentation Following Adalimumab.

Mahjoubi Yasmine Salem^1,2, Aouinti Imen^1,2, Dahmani Israa^1,2

¹National Center Chalbi Belkahia of Pharmacovigilance, Department of Collection and Analysis of Adverse Effects, Tunis, Tunisia.

Current Drug Safety

|November 1, 2024

Summary

Tumor necrosis factor alpha (TNF-α) inhibitors can cause rare facial hyperpigmentation. This side effect may be a class effect, as seen with adalimumab and certolizumab, suggesting a need for clinician awareness and sun protection.

Keywords:

Adalimumab TNF-α inhibitors adverse effects cutaneous adverse reaction drug-induced hyperpigmentation.pigmentary disorders

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Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Area of Science:

Dermatology
Immunology
Pharmacology

Background:

Tumor necrosis factor alpha (TNF-α) inhibitors are crucial for treating inflammatory diseases.
Cutaneous adverse reactions are known side effects of TNF-α inhibitor therapy.

Observation:

Two patients developed isolated facial hyperpigmentation after adalimumab treatment for ankylosing spondylitis.
Hyperpigmentation appeared as asymptomatic brown macules on the cheeks shortly after medication initiation.

Findings:

One patient's hyperpigmentation persisted post-adalimumab discontinuation; the other resolved but recurred upon switching to certolizumab.
The recurrence suggests hyperpigmentation might be a class effect of TNF-α inhibitors.

Implications:

Hyperpigmentation is an uncommon but potential adverse reaction to TNF-α inhibitors.
Clinicians should consider this side effect in patients with unexplained facial hyperpigmentation.
Sun protection is recommended for patients on TNF-α inhibitor therapy.