Related Experiment Video
Updated: Sep 5, 2025
05:25
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
19.3K
Japanese giant benign prostatic hyperplasia: Sibling cases.
Takehiro Ohyama1, Fumiyasu Endo1, Masaki Shimbo1
1Department of Urology St. Luke's International Hospital Tokyo Japan.
IJU Case Reports
|July 7, 2022
Summary
Familial benign prostatic hyperplasia (BPH) can present with giant prostates. Two brothers with significantly enlarged prostates underwent successful Holmium Laser Enucleation of the Prostate (HoLEP) for BPH treatment.
Area of Science:
- Urology
- Genetics
- Pathophysiology
Background:
- Benign prostatic hyperplasia (BPH) pathophysiology is multifactorial, with potential roles for inflammation, metabolic, and genetic factors.
- Familial clustering suggests a genetic predisposition in some BPH cases.
Observation:
- Two brothers, aged 77 and 69, presented with symptomatic giant benign prostatic hyperplasia (BPH).
- Both brothers experienced urinary retention due to the enlarged prostate volume.
Findings:
- Surgical intervention via Holmium Laser Enucleation of the Prostate (HoLEP) was performed on both patients.
- Excised prostate tissue weighed 276g and 153g, confirming massive BPH.
- Both patients experienced favorable postoperative outcomes.
Implications:
- These cases highlight the possibility of familial aggregation in benign prostatic hyperplasia.
- Giant BPH in siblings may warrant genetic counseling and consideration of hereditary factors.
- Holmium Laser Enucleation of the Prostate (HoLEP) is an effective treatment for massive BPH.
Related Concept Videos
01:20Disorders of the Male Reproductive System
558
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
558
03:09Meiosis I
41.2K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
41.2K