Related Experiment Video
Updated: Sep 5, 2025
06:08
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
365
Association Between Prostate Size and MRI Determined Quantitative Prostate Zonal Measurements
Jake Sellers1, Rachel Wagstaff1, Naseem Helo2
1Texas Tech University Health Sciences Center - School of Medicine, Department of Urology, Lubbock, TX, 79430-7260, USA.
Research and Reports in Urology
|July 7, 2022
Summary
Benign prostatic hyperplasia (BPH) growth compresses the peripheral zone (PZ) of the prostate. This PZ thinning in larger prostates may explain the lower incidence of prostate cancer (PCa) observed in men with BPH.
Area of Science:
- Urology
- Radiology
- Oncology
Background:
- Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are common in elderly men.
- An inverse relationship exists between prostate size and PCa incidence, but the interaction is unclear.
Purpose of the Study:
- To analyze prostatic zonal measurements using MRI.
- To investigate dynamic changes in the transition zone (TZ) and peripheral zone (PZ) with BPH growth.
Main Methods:
- Multiparametric MRI (mpMRI) scans from 430 male patients (age 18-89).
- Measurement of prostatic zonal areas and statistical analysis.
- Association analysis between measurements and total prostate volume (TPV).
Main Results:
- A significant decline in peripheral zone thickness (PZT) was observed in larger prostates (p < 0.0001).
- A significant negative correlation between TPV and PZT was found (-0.20, p < 0.0001).
Conclusions:
- PZT is significantly smaller in patients with higher TPV.
- Growing TZ in BPH prostates likely compresses and thins the PZ.
- This dynamic zonal change may explain BPH's protective effect against PCa.
